The concern is that frequent, long-term use has been linked in studies to possible effects on kidney function, higher blood pressure, and irritation of the stomach lining. Groups such as the American Geriatrics Society often recommend avoiding routine long-term use when possible, especially if other options may work.
Why doctors pause: These drugs are processed through the kidneys, and over time they can add extra strain—particularly at higher doses or for people who already have risk factors.
Practical tip: If you find yourself reaching for NSAIDs often, start tracking how frequently you take them. For occasional pain, acetaminophen may be an alternative that can be gentler on the stomach and kidneys when used in moderation.
Many people also find that rest, gentle movement, and heat packs reduce how often they need pain medication.
Proton Pump Inhibitors (PPIs) – Like Omeprazole and Esomeprazole
PPIs lower stomach acid and are widely used for heartburn, acid reflux, and ulcer prevention. They’re effective and commonly prescribed.
Some research suggests that using PPIs for long periods (beyond a few months) may affect absorption of nutrients such as calcium, magnesium, or vitamin B12, and in certain cases could be associated with bone health or kidney concerns. These potential links are one reason clinicians often reassess whether ongoing use is still necessary.
But there’s more to consider.
